ElectroSonic Spray Ionization (ESSI)
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Prosolia's ElectroSonic Spray Ionization (ESSI) Sources. Please
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if you have any questions about ESSI.
Overview
Prosolia’s ElectroSonic Spray Ionization (ESSI) sources represent
a significant improvement over current ESI and nano-ESI technologies,
in that they allow very large and labile molecules (and even non-covalently
bound complexes) to be gently and coolly ionized, thereby retaining
their conformational integrity while passing through, or being analyzed
by conventional mass spectrometers.
Prosolia's ESSI sources gently ionize large delicate molecules,
producing a stable and repeatable ion current that can be optimized
by tuning the applied voltage, without the need to “ignite”
the ionization process. Upon detecting mass spectra from an ESSI
source, one finds very clean mass spectra with a narrow charge state
distribution (often a single peak). Furthermore, one also finds
the almost complete elimination of peak broadening due to solvation
and adduct formation, and an insensitivity to the presence of salts
and buffers in the analyzed solution. These observations suggest
that the structural integrity of the proteins studied to date is
largely conserved by the ESSI source.
Refer to the following publication to learn more about the ElectroSonsic
Spray Ionization method.
Zoltán Takáts, Justin M. Wiseman, Bogdan Gologan,
R. Graham Cooks, “Electro-sonic Spray Ionization.
A Gentle Technique for Generating Folded Proteins and Protein Complexes
in the Gas Phase and Studying Ion-Molecule Reactions at Atmospheric
Pressure”, Analytical Chemistry, 2004, 76,
4050-4058.
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